7NBQ
Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the tricyclic inhibitor (4)
Summary for 7NBQ
Entry DOI | 10.2210/pdb7nbq/pdb |
Related | 7BKG 7BLE 7NJB 7NMB |
Descriptor | Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 2-methyl-1,2,6,7-tetrahydro-3H,5H-pyrido[3,2,1-ij]quinazolin-3-imine, ... (4 entities in total) |
Functional Keywords | methyl transferase, drug discovery, inhibitor complex, nicotinamide, metabolic disorders, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 128206.85 |
Authors | Schreuder, H.A.,Liesum, A. (deposition date: 2021-01-27, release date: 2021-03-17, Last modification date: 2024-01-31) |
Primary citation | Kannt, A.,Rajagopal, S.,Hallur, M.S.,Swamy, I.,Kristam, R.,Dhakshinamoorthy, S.,Czech, J.,Zech, G.,Schreuder, H.,Ruf, S. Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders. Molecules, 26:-, 2021 Cited by PubMed: 33668468DOI: 10.3390/molecules26040991 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.479 Å) |
Structure validation
Download full validation report