7BKG
Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the tricyclic inhibitor (2)
Summary for 7BKG
| Entry DOI | 10.2210/pdb7bkg/pdb |
| Descriptor | Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 5,6-dihydro-2-imino-2H,4H-thiazolo(5,4,3-IJ)quinoline, ... (4 entities in total) |
| Functional Keywords | methyl transferase, drug discovery, inhibitor complex, nicotinamide, metabolic disorders, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 128162.84 |
| Authors | Schreuder, H.A.,Liesum, A. (deposition date: 2021-01-15, release date: 2021-03-17, Last modification date: 2024-01-31) |
| Primary citation | Kannt, A.,Rajagopal, S.,Hallur, M.S.,Swamy, I.,Kristam, R.,Dhakshinamoorthy, S.,Czech, J.,Zech, G.,Schreuder, H.,Ruf, S. Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders. Molecules, 26:-, 2021 Cited by PubMed: 33668468DOI: 10.3390/molecules26040991 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.326 Å) |
Structure validation
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