7NBJ
Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the bisubstrate-like inhibitor (1)
Summary for 7NBJ
Entry DOI | 10.2210/pdb7nbj/pdb |
Related | 7BKG 7BLE |
Descriptor | Nicotinamide N-methyltransferase, 2-hydroxy-1-(4-(isoquinolin-5-yl)piperazin-1-yl)-2-methyl-3-(3-methyl-4-phenyl-1H-pyrazol-1-yl)propan-1-one, GLYCEROL, ... (4 entities in total) |
Functional Keywords | methyl transferase, drug discovery, inhibitor complex, nicotinamide, metabolic disorders, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 127778.43 |
Authors | Schreuder, H.A.,Liesum, A. (deposition date: 2021-01-27, release date: 2021-03-17, Last modification date: 2024-01-31) |
Primary citation | Kannt, A.,Rajagopal, S.,Hallur, M.S.,Swamy, I.,Kristam, R.,Dhakshinamoorthy, S.,Czech, J.,Zech, G.,Schreuder, H.,Ruf, S. Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders. Molecules, 26:-, 2021 Cited by PubMed: 33668468DOI: 10.3390/molecules26040991 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.275 Å) |
Structure validation
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