7NB4
Structure of Mcl-1 complex with compound 1
Summary for 7NB4
Entry DOI | 10.2210/pdb7nb4/pdb |
Related | 6ybl |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, (2~{R})-2-[[5-(3-chloranyl-2-methyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | apoptosis, apoptosis-inhibitor complex, mcl-1, s64315, small molecule inhibitor, sbdd |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20235.76 |
Authors | Dokurno, P.,Surgenor, A.E.,Kotschy, A. (deposition date: 2021-01-25, release date: 2021-10-13, Last modification date: 2024-01-31) |
Primary citation | Sipos, S.,Balint, B.,Szabo, Z.B.,Ondi, L.,Csekei, M.,Szlavik, Z.,Proszenyak, A.,Murray, J.B.,Davidson, J.,Chen, I.,Dokurno, P.,Surgenor, A.E.,Pedder, C.,Hubbard, R.E.,Maragno, A.L.,Chanrion, M.,Colland, F.,Geneste, O.,Kotschy, A. The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues. Acs Omega, 6:22073-22102, 2021 Cited by PubMed: 34497901DOI: 10.1021/acsomega.1c02595 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report