7NB4
Structure of Mcl-1 complex with compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 170 | 19493.2 | 1 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | B (A) | (2~{R})-2-[[5-(3-chloranyl-2-methyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid | non-polymer | 452.0 | 1 | Chemie (U6Q) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE | non-polymer | 266.3 | 1 | Chemie (PG6) | |||
| 5 | E (A) | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
A: 171 - 327 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Met 158 | - | initiating methionine |
| His 159 | - | expression tag |
| His 160 | - | expression tag |
| His 161 | - | expression tag |
| His 162 | - | expression tag |
| His 163 | - | expression tag |
| His 164 | - | expression tag |
| Leu 165 | - | expression tag |
| Val 166 | - | expression tag |
| Pro 167 | - | expression tag |
| Arg 168 | - | expression tag |
| Gly 169 | - | expression tag |
| Ser 170 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19493.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 742.6 | |
| All* | Total formula weight | 20235.8 |
