7NAJ
Crystal structure of the TIR domain from human SARM1 in complex with ara-2'F-ADPR
Summary for 7NAJ
Entry DOI | 10.2210/pdb7naj/pdb |
Descriptor | Sterile alpha and TIR motif-containing protein 1, 1,4-anhydro-2-deoxy-2-fluoro-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-D-arabinitol (3 entities in total) |
Functional Keywords | nadase, axon degeneration, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 33259.57 |
Authors | |
Primary citation | Shi, Y.,Kerry, P.S.,Nanson, J.D.,Bosanac, T.,Sasaki, Y.,Krauss, R.,Saikot, F.K.,Adams, S.E.,Mosaiab, T.,Masic, V.,Mao, X.,Rose, F.,Vasquez, E.,Furrer, M.,Cunnea, K.,Brearley, A.,Gu, W.,Luo, Z.,Brillault, L.,Landsberg, M.J.,DiAntonio, A.,Kobe, B.,Milbrandt, J.,Hughes, R.O.,Ve, T. Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Mol.Cell, 82:1643-, 2022 Cited by PubMed: 35334231DOI: 10.1016/j.molcel.2022.03.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report