7NAJ

Crystal structure of the TIR domain from human SARM1 in complex with ara-2'F-ADPR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Sterile alpha and TIR motif-containing protein 1	polymer	144	16333.7	2	UniProt (Q6SZW1) Pfam (PF13676)	Homo sapiens (Human)	Sterile alpha and Armadillo repeat protein,Sterile alpha motif domain-containing protein 2,SAM domain-containing protein 2,Tir-1 homolog
2	C, D (A, B)	1,4-anhydro-2-deoxy-2-fluoro-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-D-arabinitol	non-polymer		296.1	2	Chemie (1LK)
3	E, F (A, B)	water	water		18.0	123	Chemie (HOH)

Sequence modifications

A, B: 560 - 700 (UniProt: Q6SZW1)

PDB	External Database	Details
Ser 557	-	expression tag
Asn 558	-	expression tag
Ala 559	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32667.4
Non-Polymers*	Number of molecules	2
	Total formula weight	592.2
All*	Total formula weight	33259.6

*Water molecules are not included.