7N9O

Estrogen Receptor Alpha Ligand Binding Domain in Complex with Aliphatic SERD S-C10(15)

Summary for 7N9O

• Entry DOI: 10.2210/pdb7n9o/pdb
• Descriptor: Estrogen receptor, 10-{[3,17beta-dihydroxyestra-1,3,5(10)-trien-7beta-yl]sulfanyl}-N-methyl-N-propyldecanamide (3 entities in total)
• Functional Keywords: breast cancer, selective estrogen receptor degrader, aliphatic serd, antagonist, alpha helical bundle, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 115540.10

Authors

Diennet, M.,El Ezzy, M.,Thiombane, K.,Cotnoir-White, D.,Poupart, J.,Gao, Z.,Mendoza, S.R.,Marinier, A.,Gleason, J.,Mader, S.C.,Fanning, S.W. (deposition date: 2021-06-18, release date: 2022-07-06, Last modification date: 2023-10-18)

• Primary citation: Fanning, S.W.,Mader, S.C.; Estrogen Receptor Alpha Ligand Binding Domain in Complex with Aliphatic SERD S-C10(15); To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)