7N9O
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Aliphatic SERD S-C10(15)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Estrogen receptor | polymer | 249 | 28355.2 | 4 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | E, F, G, H (A, B, C, D) | 10-{[3,17beta-dihydroxyestra-1,3,5(10)-trien-7beta-yl]sulfanyl}-N-methyl-N-propyldecanamide | non-polymer | 529.8 | 4 | Chemie (5YR) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 543 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 306 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 113420.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2119.3 | |
| All* | Total formula weight | 115540.1 |
