7MYJ
Structure of full length human AMPK (a2b1g1) in complex with a small molecule activator MSG011
Summary for 7MYJ
Entry DOI | 10.2210/pdb7myj/pdb |
Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (6 entities in total) |
Functional Keywords | activator, kinase, ampk, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 268660.49 |
Authors | Ovens, A.J.,Gee, Y.S.,Ling, N.X.Y.,Waters, N.J.,Yu, D.,Scott, J.W.,Parker, M.W.,Hoffman, N.J.,Kemp, B.E.,Baell, J.B.,Oakhill, J.S.,Langendorf, C.G. (deposition date: 2021-05-21, release date: 2022-06-29, Last modification date: 2023-10-18) |
Primary citation | Ovens, A.J.,Gee, Y.S.,Ling, N.X.Y.,Yu, D.,Hardee, J.P.,Chung, J.D.,Ngoei, K.R.W.,Waters, N.J.,Hoffman, N.J.,Scott, J.W.,Loh, K.,Spengler, K.,Heller, R.,Parker, M.W.,Lynch, G.S.,Huang, F.,Galic, S.,Kemp, B.E.,Baell, J.B.,Oakhill, J.S.,Langendorf, C.G. Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator. Biochem.J., 479:1181-1204, 2022 Cited by PubMed: 35552369DOI: 10.1042/BCJ20220067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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