7MU5
Human DCTPP1 bound to Triptolide
Summary for 7MU5
Entry DOI | 10.2210/pdb7mu5/pdb |
Descriptor | dCTP pyrophosphatase 1, MAGNESIUM ION, triptolide, ... (4 entities in total) |
Functional Keywords | inhibitor, pyrophosphatase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 8 |
Total formula weight | 104520.08 |
Authors | Hauk, G.,Berger, J.M. (deposition date: 2021-05-14, release date: 2022-08-24, Last modification date: 2023-10-18) |
Primary citation | Liu, J.,He, Q.-L.,Zhou, J.,Chikarmane, R.V.,Hauk, G.,Rachakonda, A.,Vaghasia, A.M.,Castagna, N.,Steinberg, R.C.,Anders, N.M.,Wanjiku, T.M.,Nuhn, P.,Shim, J.S.,Giovinazzo, H.,Esopi, D.M.,Kim, K.,Coulter, J.,Wang, R.,Zhou, J.,Rudek, M.A.,Berger, J.M.,Liu, J.O.,Nelson, W.G.,Yegnasubramanian, S. Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report