7LFN

Structure of Hyperglycosylated Human IgG1 Fc (Fc267_329)

Summary for 7LFN

• Entry DOI: 10.2210/pdb7lfn/pdb
• Descriptor: IgG1 Fc (Fc267_329), alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: effector, igg, antibody, fc, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 56560.05

Authors

Fields, J.K.,Sundberg, E.J. (deposition date: 2021-01-17, release date: 2021-01-27, Last modification date: 2023-10-18)

• Primary citation: Fields, J.K.,Sundberg, E.J.; Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)