7LD3
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand
Summary for 7LD3
Entry DOI | 10.2210/pdb7ld3/pdb |
EMDB information | 23280 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-2, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total) |
Functional Keywords | signaling protein, membrane protein, active-state g protein-coupled receptor, adenosine a1 receptor, pam, allosteric modulator |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 130876.13 |
Authors | Draper-Joyce, C.J.,Danev, R.,Thal, D.M.,Christopoulos, A.,Glukhova, A. (deposition date: 2021-01-12, release date: 2021-09-08, Last modification date: 2021-10-13) |
Primary citation | Draper-Joyce, C.J.,Bhola, R.,Wang, J.,Bhattarai, A.,Nguyen, A.T.N.,Cowie-Kent, I.,O'Sullivan, K.,Chia, L.Y.,Venugopal, H.,Valant, C.,Thal, D.M.,Wootten, D.,Panel, N.,Carlsson, J.,Christie, M.J.,White, P.J.,Scammells, P.,May, L.T.,Sexton, P.M.,Danev, R.,Miao, Y.,Glukhova, A.,Imlach, W.L.,Christopoulos, A. Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature, 597:571-576, 2021 Cited by PubMed: 34497422DOI: 10.1038/s41586-021-03897-2 PDB entries with the same primary citation |
Experimental method |
Structure validation
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