7L7F

Cryo-EM structure of human ACE2 receptor bound to protein encoded by vaccine candidate BNT162b1

Summary for 7L7F

• Entry DOI: 10.2210/pdb7l7f/pdb
• EMDB information: 23211
• Descriptor: Angiotensin-converting enzyme 2, Spike glycoprotein, Envelope glycoprotein fusion (2 entities in total)
• Functional Keywords: sars-cov-2, covid19, bnt162b1, viral protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 244093.95

Authors

Lees, J.A.,Han, S. (deposition date: 2020-12-28, release date: 2021-02-24, Last modification date: 2021-04-21)

• Primary citation: Vogel, A.B.,Kanevsky, I.,Che, Y.,Swanson, K.A.,Muik, A.,Vormehr, M.,Kranz, L.M.,Walzer, K.C.,Hein, S.,Guler, A.,Loschko, J.,Maddur, M.S.,Ota-Setlik, A.,Tompkins, K.,Cole, J.,Lui, B.G.,Ziegenhals, T.,Plaschke, A.,Eisel, D.,Dany, S.C.,Fesser, S.,Erbar, S.,Bates, F.,Schneider, D.,Jesionek, B.,Sanger, B.,Wallisch, A.K.,Feuchter, Y.,Junginger, H.,Krumm, S.A.,Heinen, A.P.,Adams-Quack, P.,Schlereth, J.,Schille, S.,Kroner, C.,de la Caridad Guimil Garcia, R.,Hiller, T.,Fischer, L.,Sellers, R.S.,Choudhary, S.,Gonzalez, O.,Vascotto, F.,Gutman, M.R.,Fontenot, J.A.,Hall-Ursone, S.,Brasky, K.,Griffor, M.C.,Han, S.,Su, A.A.H.,Lees, J.A.,Nedoma, N.L.,Mashalidis, E.H.,Sahasrabudhe, P.V.,Tan, C.Y.,Pavliakova, D.,Singh, G.,Fontes-Garfias, C.,Pride, M.,Scully, I.L.,Ciolino, T.,Obregon, J.,Gazi, M.,Carrion Jr., R.,Alfson, K.J.,Kalina, W.V.,Kaushal, D.,Shi, P.Y.,Klamp, T.,Rosenbaum, C.,Kuhn, A.N.,Tureci, O.,Dormitzer, P.R.,Jansen, K.U.,Sahin, U.; BNT162b vaccines protect rhesus macaques from SARS-CoV-2.; Nature, 592:283-289, 2021; PubMed: 33524990; DOI: 10.1038/s41586-021-03275-y

Experimental method

ELECTRON MICROSCOPY (3.24 Å)