7L7F
Cryo-EM structure of human ACE2 receptor bound to protein encoded by vaccine candidate BNT162b1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (B, D) | Angiotensin-converting enzyme 2 | polymer | 805 | 92556.7 | 2 | UniProt (Q9BYF1) Pfam (PF01401) Pfam (PF16959) | Homo sapiens (Human) | Angiotensin-converting enzyme homolog,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15 |
| 2 | B, D (E, F) | Spike glycoprotein, Envelope glycoprotein fusion | polymer | 266 | 29490.3 | 2 | UniProt (P0DTC2) UniProt (M1E1E4) Pfam (PF09408) UniProt (by SIFTS) (P10104) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | S glycoprotein,E2,Peplomer protein |
Sequence modifications
E, F: 311 - 326 (UniProt: P0DTC2)
E, F: 327 - 528 (UniProt: P0DTC2)
E, F: 538 - 565 (UniProt: M1E1E4)
E, F: 327 - 528 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Gly 529 | - | linker |
| Ser 530 | - | linker |
| Pro 531 | - | linker |
| Gly 532 | - | linker |
| Ser 533 | - | linker |
| Gly 534 | - | linker |
| Ser 535 | - | linker |
| Gly 536 | - | linker |
| Ser 537 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Arg 566 | - | expression tag |
| Ser 567 | - | expression tag |
| Leu 568 | - | expression tag |
| Glu 569 | - | expression tag |
| Val 570 | - | expression tag |
| Leu 571 | - | expression tag |
| Phe 572 | - | expression tag |
| Gln 573 | - | expression tag |
| Gly 574 | - | expression tag |
| Pro 575 | - | expression tag |
| Gly 576 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 244094.0 | |
| All* | Total formula weight | 244094.0 |
