7KN6
Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobody VHH V and antibody Fab CC12.3
Summary for 7KN6
Entry DOI | 10.2210/pdb7kn6/pdb |
Descriptor | Spike protein S1, VHH V, CC12.3 Fab heavy chain, ... (5 entities in total) |
Functional Keywords | sars-cov-2, nanobody, spike, coronavirus, covid-19, immune system, nanobody-antigen complex, single-domain antibody, antibody, viral protein, viral protein-immune system complex, viral protein/immune system |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More |
Total number of polymer chains | 4 |
Total formula weight | 87517.43 |
Authors | Liu, H.,Yuan, M.,Zhu, X.,Wu, N.C.,Wilson, I.A. (deposition date: 2020-11-04, release date: 2021-01-20, Last modification date: 2023-10-18) |
Primary citation | Koenig, P.A.,Das, H.,Liu, H.,Kummerer, B.M.,Gohr, F.N.,Jenster, L.M.,Schiffelers, L.D.J.,Tesfamariam, Y.M.,Uchima, M.,Wuerth, J.D.,Gatterdam, K.,Ruetalo, N.,Christensen, M.H.,Fandrey, C.I.,Normann, S.,Todtmann, J.M.P.,Pritzl, S.,Hanke, L.,Boos, J.,Yuan, M.,Zhu, X.,Schmid-Burgk, J.L.,Kato, H.,Schindler, M.,Wilson, I.A.,Geyer, M.,Ludwig, K.U.,Hallberg, B.M.,Wu, N.C.,Schmidt, F.I. Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science, 371:-, 2021 Cited by PubMed: 33436526DOI: 10.1126/science.abe6230 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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