7KH8
Human LMPTP in complex with inhibitor
Summary for 7KH8
Entry DOI | 10.2210/pdb7kh8/pdb |
Descriptor | Low molecular weight phosphotyrosine protein phosphatase, 3-[(2,6-dichlorophenyl)methyl]-8-(2-methylphenyl)-3H-purin-6-amine, NITRATE ION, ... (4 entities in total) |
Functional Keywords | protein tyrosine phosphatase, lmwptp, inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 36609.01 |
Authors | Stanford, S.M.,Diaz, M.A.,Ardecky, R.J.,Zou, J.,Roosild, T.,Holmes, Z.J.,Hedrick, M.P.,Rodiles, S.,Santelli, E.,Chung, T.D.Y.,Jackson, M.R.,Bottini, N.,Pinkerton, A.B. (deposition date: 2020-10-20, release date: 2021-05-19, Last modification date: 2023-10-18) |
Primary citation | Stanford, S.M.,Diaz, M.A.,Ardecky, R.J.,Zou, J.,Roosild, T.,Holmes, Z.J.,Nguyen, T.P.,Hedrick, M.P.,Rodiles, S.,Guan, A.,Grotegut, S.,Santelli, E.,Chung, T.D.Y.,Jackson, M.R.,Bottini, N.,Pinkerton, A.B. Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. J.Med.Chem., 64:5645-5653, 2021 Cited by PubMed: 33914534DOI: 10.1021/acs.jmedchem.0c02126 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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