7KH8
Human LMPTP in complex with inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003993 | molecular_function | acid phosphatase activity |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0003993 | molecular_function | acid phosphatase activity |
| B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0042383 | cellular_component | sarcolemma |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue WE7 A 201 |
| Chain | Residue |
| A | LEU13 |
| A | NO3202 |
| A | HOH410 |
| A | HOH493 |
| B | WE7201 |
| A | GLY14 |
| A | ILE16 |
| A | SER47 |
| A | TYR49 |
| A | GLU50 |
| A | ASP129 |
| A | TYR131 |
| A | TYR132 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue NO3 A 202 |
| Chain | Residue |
| A | CYS12 |
| A | LEU13 |
| A | GLY14 |
| A | ASN15 |
| A | ILE16 |
| A | CYS17 |
| A | ARG18 |
| A | WE7201 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue WE7 B 201 |
| Chain | Residue |
| A | WE7201 |
| B | GLY14 |
| B | ILE16 |
| B | SER47 |
| B | TYR49 |
| B | GLU50 |
| B | ASP129 |
| B | TYR131 |
| B | TYR132 |
| B | NO3202 |
| B | HOH517 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue NO3 B 202 |
| Chain | Residue |
| B | CYS12 |
| B | LEU13 |
| B | GLY14 |
| B | ASN15 |
| B | ILE16 |
| B | CYS17 |
| B | ARG18 |
| B | WE7201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P11064 |
| Chain | Residue | Details |
| B | CYS12 | |
| A | CYS12 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P11064 |
| Chain | Residue | Details |
| B | ARG18 | |
| A | ARG18 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P11064 |
| Chain | Residue | Details |
| B | ASP129 | |
| A | ASP129 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:9038134 |
| Chain | Residue | Details |
| B | TYR131 | |
| B | TYR132 | |
| A | TYR131 | |
| A | TYR132 |
