7KBG
Structure of Human HDAC2 in complex with a 2-substituted benzamide inhibitor (compound 20)
Summary for 7KBG
Entry DOI | 10.2210/pdb7kbg/pdb |
Descriptor | Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (9 entities in total) |
Functional Keywords | histone deacetylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 133318.19 |
Authors | Klein, D.J.,Liu, J. (deposition date: 2020-10-02, release date: 2020-12-30, Last modification date: 2024-03-06) |
Primary citation | Liu, J.,Yu, Y.,Kelly, J.,Sha, D.,Alhassan, A.B.,Yu, W.,Maletic, M.M.,Duffy, J.L.,Klein, D.J.,Holloway, M.K.,Carroll, S.,Howell, B.J.,Barnard, R.J.O.,Wolkenberg, S.,Kozlowski, J.A. Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group. Acs Med.Chem.Lett., 11:2476-2483, 2020 Cited by PubMed: 33335670DOI: 10.1021/acsmedchemlett.0c00462 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.26 Å) |
Structure validation
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