7K65
Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23
Summary for 7K65
Entry DOI | 10.2210/pdb7k65/pdb |
EMDB information | 22689 |
Descriptor | Protein patched homolog 1, nanobody TI23, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | membrane protein |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 162633.06 |
Authors | Zhang, Y.,Bulkley, D.P.,Liang, J.,Manglik, A.,Cheng, Y.,Beachy, P.A. (deposition date: 2020-09-18, release date: 2021-03-17) |
Primary citation | Zhang, Y.,Lu, W.J.,Bulkley, D.P.,Liang, J.,Ralko, A.,Han, S.,Roberts, K.J.,Li, A.,Cho, W.,Cheng, Y.,Manglik, A.,Beachy, P.A. Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit. Proc.Natl.Acad.Sci.USA, 117:28838-28846, 2020 Cited by PubMed: 33139559DOI: 10.1073/pnas.2011560117 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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