7K65
Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein patched homolog 1 | polymer | 1281 | 142619.9 | 1 | UniProt (Q61115) Pfam (PF12349) Pfam (PF02460) | Mus musculus (Mouse) | PTC1 |
| 2 | B (B) | nanobody TI23 | polymer | 124 | 13821.4 | 1 | Lama glama | ||
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D, E, F, G, H (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 5 | I, J, K, L (A) | 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside | non-polymer | 1165.3 | 4 | Chemie (Q7G) |
Sequence modifications
A: 1 - 1291 (UniProt: Q61115)
| PDB | External Database | Details |
|---|---|---|
| - | His 620 | deletion |
| - | Ser 621 | deletion |
| - | Asn 622 | deletion |
| - | Thr 623 | deletion |
| - | Arg 624 | deletion |
| - | Tyr 625 | deletion |
| - | Ser 626 | deletion |
| - | Pro 627 | deletion |
| - | Pro 628 | deletion |
| - | Pro 629 | deletion |
| - | Pro 630 | deletion |
| - | Tyr 631 | deletion |
| - | Thr 632 | deletion |
| - | Ser 633 | deletion |
| - | His 634 | deletion |
| - | Ser 635 | deletion |
| - | Phe 636 | deletion |
| - | Ala 637 | deletion |
| - | His 638 | deletion |
| - | Glu 639 | deletion |
| - | Thr 640 | deletion |
| - | His 641 | deletion |
| - | Ile 642 | deletion |
| - | Thr 643 | deletion |
| Met 1292 | - | expression tag |
| Asp 1293 | - | expression tag |
| Glu 1294 | - | expression tag |
| Lys 1295 | - | expression tag |
| Thr 1296 | - | expression tag |
| Thr 1297 | - | expression tag |
| Gly 1298 | - | expression tag |
| Trp 1299 | - | expression tag |
| Arg 1300 | - | expression tag |
| Gly 1301 | - | expression tag |
| Gly 1302 | - | expression tag |
| His 1303 | - | expression tag |
| Val 1304 | - | expression tag |
| Val 1305 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 156441.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 5767.3 | |
| All* | Total formula weight | 162633.1 |
