7JV8
Human CD73 (ecto 5'-nucleotidase) in complex with compound 35
Summary for 7JV8
Entry DOI | 10.2210/pdb7jv8/pdb |
Descriptor | 5'-nucleotidase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | 5'-nucleotidase, hydrolase, phosphatase, proteros, proteros biostructures gmbh, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 237898.68 |
Authors | Gibbons, P.,Du, X. (deposition date: 2020-08-20, release date: 2020-09-23, Last modification date: 2023-10-18) |
Primary citation | Du, X.,Moore, J.,Blank, B.R.,Eksterowicz, J.,Sutimantanapi, D.,Yuen, N.,Metzger, T.,Chan, B.,Huang, T.,Chen, X.,Chen, Y.,Duong, F.,Kong, W.,Chang, J.H.,Sun, J.,Zavorotinskaya, T.,Ye, Q.,Junttila, M.R.,Ndubaku, C.,Friedman, L.S.,Fantin, V.R.,Sun, D. Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production. J.Med.Chem., 63:10433-10459, 2020 Cited by PubMed: 32865411DOI: 10.1021/acs.jmedchem.0c01086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.46 Å) |
Structure validation
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