7JV8
Human CD73 (ecto 5'-nucleotidase) in complex with compound 35
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | 5'-nucleotidase | polymer | 529 | 58765.9 | 4 | UniProt (P21589) Pfam (PF00149) Pfam (PF02872) In PDB | Homo sapiens (Human) | 5'-NT,Ecto-5'-nucleotidase |
| 2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | A, B, C, D | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 4 | A, B, C, D | 6-chloro-N-cyclopentyl-1-{5-O-[(2R)-1-hydroxy-3-methoxy-2-phosphonopropan-2-yl]-beta-D-ribofuranosyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine | non-polymer | 537.9 | 4 | Chemie (VPD) | |||
| 5 | water | water | 18.0 | 501 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 27 - 549 (UniProt: P21589)
| PDB | External Database | Details |
|---|---|---|
| Leu 23 | - | expression tag |
| Ala 24 | - | expression tag |
| Ser 25 | - | expression tag |
| Met 26 | - | expression tag |
| Asp 53 | Asn 53 | engineered mutation |
| Asp 333 | Asn 333 | engineered mutation |
| Asp 403 | Asn 403 | engineered mutation |
| His 550 | - | expression tag |
| His 551 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 235063.5 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2835.1 | |
| All* | Total formula weight | 237898.7 |
