7JR8
H-PDGS complexed with a 2-phenylimidazo[1,2-a]pyridine-6-carboxamide inhibitors
Summary for 7JR8
Entry DOI | 10.2210/pdb7jr8/pdb |
Related | 6ZTC 7JR6 |
Descriptor | Hematopoietic prostaglandin D synthase, CHLORIDE ION, 1,2-ETHANEDIOL, ... (8 entities in total) |
Functional Keywords | hematopoietic prostaglandin d2 synthase, inhibitor, isomerase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 48564.61 |
Authors | Nolte, R.T.,Somers, D.O.,Gampe, R.T. (deposition date: 2020-08-11, release date: 2021-05-26, Last modification date: 2024-03-06) |
Primary citation | Schulte, C.A.,Deaton, D.N.,Diaz, E.,Do, Y.,Gampe, R.T.,Guss, J.H.,Hancock, A.P.,Hobbs, H.,Hodgson, S.T.,Holt, J.,Jeune, M.R.,Kahler, K.M.,Kramer, H.F.,Le, J.,Mortenson, P.N.,Musetti, C.,Nolte, R.T.,Orband-Miller, L.A.,Peckham, G.E.,Petrov, K.G.,Pietrak, B.L.,Poole, C.,Price, D.J.,Saxty, G.,Shillings, A.,Smalley Jr., T.L.,Somers, D.O.,Stewart, E.L.,Stuart, J.D.,Thomson, S.A. A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors. Bioorg.Med.Chem.Lett., 47:128113-128113, 2021 Cited by PubMed: 33991628DOI: 10.1016/j.bmcl.2021.128113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.13 Å) |
Structure validation
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