7JR8
H-PDGS complexed with a 2-phenylimidazo[1,2-a]pyridine-6-carboxamide inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hematopoietic prostaglandin D synthase | polymer | 200 | 23427.9 | 2 | UniProt (O60760) Pfam (PF02798) Pfam (PF14497) | Homo sapiens (Human) | H-PGDS,GST class-sigma,Glutathione S-transferase,Glutathione-dependent PGD synthase,Glutathione-requiring prostaglandin D synthase,Prostaglandin-H2 D-isomerase |
| 2 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | D, E, H (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | F, I (A, B) | GLUTATHIONE | non-polymer | 307.3 | 2 | Chemie (GSH) | |||
| 5 | G, J (A, B) | N-[trans-4-(2-hydroxypropan-2-yl)cyclohexyl]-2-phenylimidazo[1,2-a]pyridine-6-carboxamide | non-polymer | 377.5 | 2 | Chemie (VH7) | |||
| 6 | K, L (B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | M, N, O (B) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 8 | P, Q (A, B) | water | water | 18.0 | 595 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 199 (UniProt: O60760)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46855.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1708.8 | |
| All* | Total formula weight | 48564.6 |
