7JG0
Human GAR transformylase in complex with GAR substrate and AGF102 inhibitor
Summary for 7JG0
Entry DOI | 10.2210/pdb7jg0/pdb |
Related | 7JG3 7JG4 |
Descriptor | Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]thiophene-2-carbonyl}-L-glutamic acid, ... (4 entities in total) |
Functional Keywords | garftase, formyltransferase, transformylase, enzyme protein inhibitor, metabolism, alpha beta protein, rossman fold, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 23572.84 |
Authors | Wong-Roushar, J.,Dann III, C.E. (deposition date: 2020-07-18, release date: 2021-03-31, Last modification date: 2023-10-18) |
Primary citation | Wallace-Povirk, A.,Tong, N.,Wong-Roushar, J.,O'Connor, C.,Zhou, X.,Hou, Z.,Bao, X.,Garcia, G.E.,Li, J.,Kim, S.,Dann, C.E.,Matherly, L.H.,Gangjee, A. Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors Bioorg.Med.Chem., 37:116093-, 2021 Cited by DOI: 10.1016/j.bmc.2021.116093PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.984 Å) |
Structure validation
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