7JG0

Human GAR transformylase in complex with GAR substrate and AGF102 inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0009058	biological_process	biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue GAR A 1101

Chain	Residue
A	THR816
A	LYS976
A	GLU979
A	V971102
A	HOH1206
A	HOH1225
A	HOH1229
A	HOH1237
A	HOH1245
A	HOH1252
A	HOH1255
A	GLY817
A	SER818
A	ASN819
A	GLY893
A	MET895
A	HIS914
A	PRO915
A	GLY923

---

site_id	AC2
Number of Residues	16
Details	binding site for residue V97 A 1102

Chain	Residue
A	HIS864
A	ARG870
A	PHE894
A	MET895
A	ARG896
A	ILE897
A	LEU898
A	VAL903
A	ASN912
A	VAL945
A	ALA946
A	GLU947
A	VAL949
A	ASP950
A	GAR1101
A	HOH1207

---

Functional Information from PROSITE/UniProt

site_id	PS00373
Number of Residues	24
Details	GART Phosphoribosylglycinamide formyltransferase active site. GcTVhFVaEdVDaGqiIlqeavpV

Chain	Residue	Details
A	GLY939-VAL962

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P08179

Chain	Residue	Details
A	HIS914

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:12450384, ECO:0000269|PubMed:16026156, ECO:0007744|PDB:1MEN, ECO:0007744|PDB:1ZLY

Chain	Residue	Details
A	GLY817
A	LYS976

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0007744|PDB:1NJS

Chain	Residue	Details
A	ARG870
A	ASN912

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:16026156, ECO:0007744|PDB:1NJS, ECO:0007744|PDB:1ZLY

Chain	Residue	Details
A	MET895
A	ALA946

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Raises pKa of active site His => ECO:0000250|UniProtKB:P08179

Chain	Residue	Details
A	ASP950

---