7JG0
Human GAR transformylase in complex with GAR substrate and AGF102 inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue GAR A 1101 |
| Chain | Residue |
| A | THR816 |
| A | LYS976 |
| A | GLU979 |
| A | V971102 |
| A | HOH1206 |
| A | HOH1225 |
| A | HOH1229 |
| A | HOH1237 |
| A | HOH1245 |
| A | HOH1252 |
| A | HOH1255 |
| A | GLY817 |
| A | SER818 |
| A | ASN819 |
| A | GLY893 |
| A | MET895 |
| A | HIS914 |
| A | PRO915 |
| A | GLY923 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue V97 A 1102 |
| Chain | Residue |
| A | HIS864 |
| A | ARG870 |
| A | PHE894 |
| A | MET895 |
| A | ARG896 |
| A | ILE897 |
| A | LEU898 |
| A | VAL903 |
| A | ASN912 |
| A | VAL945 |
| A | ALA946 |
| A | GLU947 |
| A | VAL949 |
| A | ASP950 |
| A | GAR1101 |
| A | HOH1207 |
Functional Information from PROSITE/UniProt
| site_id | PS00373 |
| Number of Residues | 24 |
| Details | GART Phosphoribosylglycinamide formyltransferase active site. GcTVhFVaEdVDaGqiIlqeavpV |
| Chain | Residue | Details |
| A | GLY939-VAL962 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P08179","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12450384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16026156","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MEN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZLY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12755606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1NJS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12755606","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16026156","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1NJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZLY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Raises pKa of active site His","evidences":[{"source":"UniProtKB","id":"P08179","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
