7FIY

Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex

Summary for 7FIY

Entry DOI	10.2210/pdb7fiy/pdb
EMDB information	31606
Descriptor	Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, Tiezepatide, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (7 entities in total)
Functional Keywords	cryo-electron microscopy; g protein-coupled receptor; ligand recognition; receptor activation; unimolecular agonist, structural protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	180517.74
Authors	Zhao, F.H.,Zhou, Q.T.,Cong, Z.T.,Hang, K.N.,Zou, X.Y.,Zhang, C.,Chen, Y.,Dai, A.T.,Liang, A.Y.,Ming, Q.Q.,Wang, M.,Chen, L.N.,Xu, P.Y.,Chang, R.L.,Feng, W.B.,Xia, T.,Zhang, Y.,Wu, B.L.,Yang, D.H.,Zhao, L.H.,Xu, H.E.,Wang, M.W. (deposition date: 2021-08-01, release date: 2022-03-02, Last modification date: 2022-03-16)
Primary citation	Zhao, F.,Zhou, Q.,Cong, Z.,Hang, K.,Zou, X.,Zhang, C.,Chen, Y.,Dai, A.,Liang, A.,Ming, Q.,Wang, M.,Chen, L.N.,Xu, P.,Chang, R.,Feng, W.,Xia, T.,Zhang, Y.,Wu, B.,Yang, D.,Zhao, L.,Xu, H.E.,Wang, M.W. Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13:1057-1057, 2022 Cited by PubMed: 35217653 DOI: 10.1038/s41467-022-28683-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation