7VSI

Structure of human SGLT2-MAP17 complex bound with empagliflozin

Replaces:  7FEN

Summary for 7VSI

• Entry DOI: 10.2210/pdb7vsi/pdb
• EMDB information: 31558
• Descriptor: Sodium/glucose cotransporter 2, PDZK1-interacting protein 1, PALMITIC ACID, ... (4 entities in total)
• Functional Keywords: glucose transporter, sglt2, sglt, transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 79850.31

Authors

Chen, L.,Niu, Y.,Liu, R. (deposition date: 2021-10-26, release date: 2021-12-15, Last modification date: 2022-02-16)

• Primary citation: Niu, Y.,Liu, R.,Guan, C.,Zhang, Y.,Chen, Z.,Hoerer, S.,Nar, H.,Chen, L.; Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter.; Nature, 601:280-284, 2022; PubMed: 34880493; DOI: 10.1038/s41586-021-04212-9

Experimental method

ELECTRON MICROSCOPY (2.95 Å)