7F83
Crystal Structure of a receptor in Complex with inverse agonist
Summary for 7F83
Entry DOI | 10.2210/pdb7f83/pdb |
Descriptor | Growth hormone secretagogue receptor type 1,Soluble cytochrome b562, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone (3 entities in total) |
Functional Keywords | gpcr, ghrelin, inverse agonist, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 97531.02 |
Authors | |
Primary citation | Qin, J.,Cai, Y.,Xu, Z.,Ming, Q.,Ji, S.Y.,Wu, C.,Zhang, H.,Mao, C.,Shen, D.D.,Hirata, K.,Ma, Y.,Yan, W.,Zhang, Y.,Shao, Z. Molecular mechanism of agonism and inverse agonism in ghrelin receptor. Nat Commun, 13:300-300, 2022 Cited by PubMed: 35027551DOI: 10.1038/s41467-022-27975-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.94 Å) |
Structure validation
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