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7F83

Crystal Structure of a receptor in Complex with inverse agonist

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Growth hormone secretagogue receptor type 1,Soluble cytochrome b562polymer41647183.22UniProt (Q92847)
UniProt (P0ABE7)
Pfam (PF00001)
Homo sapiens (human)GHS-R,GH-releasing peptide receptor,GHRP,Ghrelin receptor,Cytochrome b-562
2C, D, F, G, H...
(A, B)
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoatenon-polymer356.56Chemie (OLC)
3E, J
(A, B)
2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanonenon-polymer512.72Chemie (1KQ)
Sequence modifications
A, B: 35 - 243 (UniProt: Q92847)
PDBExternal DatabaseDetails
Lys 130Thr 130engineered mutation
Gln 188Asn 188engineered mutation
A, B: 1006 - 1111 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Trp 1012Met 29engineered mutation
Ile 1107His 124engineered mutation
Leu 1111Arg 128engineered mutation
A, B: 253 - 342 (UniProt: Q92847)
PDBExternal DatabaseDetails
Gly 1001-linker
Gly 1002-linker
Thr 1003-linker
Thr 1004-linker
Met 1005-linker
Glu 343-expression tag
Asn 344-expression tag
Leu 345-expression tag
Tyr 346-expression tag
Phe 347-expression tag
Gln 348-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight94366.4
Non-Polymers*Number of molecules8
Total formula weight3164.6
All*Total formula weight97531.0
*Water molecules are not included.

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PDB entries from 2025-07-02

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