7F83
Crystal Structure of a receptor in Complex with inverse agonist
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Growth hormone secretagogue receptor type 1,Soluble cytochrome b562 | polymer | 416 | 47183.2 | 2 | UniProt (Q92847) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB | Homo sapiens (human) | GHS-R,GH-releasing peptide receptor,GHRP,Ghrelin receptor,Cytochrome b-562 |
2 | A, B | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 6 | Chemie (OLC) | |||
3 | A, B | 2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone | non-polymer | 512.7 | 2 | Chemie (1KQ) |
Sequence modifications
A, B: 35 - 243 (UniProt: Q92847)
A, B: 1006 - 1111 (UniProt: P0ABE7)
A, B: 253 - 342 (UniProt: Q92847)
PDB | External Database | Details |
---|---|---|
Lys 130 | Thr 130 | engineered mutation |
Gln 188 | Asn 188 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Trp 1012 | Met 29 | engineered mutation |
Ile 1107 | His 124 | engineered mutation |
Leu 1111 | Arg 128 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 1001 | - | linker |
Gly 1002 | - | linker |
Thr 1003 | - | linker |
Thr 1004 | - | linker |
Met 1005 | - | linker |
Glu 343 | - | expression tag |
Asn 344 | - | expression tag |
Leu 345 | - | expression tag |
Tyr 346 | - | expression tag |
Phe 347 | - | expression tag |
Gln 348 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 94366.4 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 3164.6 | |
All* | Total formula weight | 97531.0 |