7F2K
Crystal structure of PDE4D catalytic domain complexed with compound 17a
Summary for 7F2K
Entry DOI | 10.2210/pdb7f2k/pdb |
Descriptor | Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pde4 inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 116883.47 |
Authors | Huang, Y.-Y.,He, X.,Luo, H.-B. (deposition date: 2021-06-11, release date: 2021-10-20, Last modification date: 2023-11-29) |
Primary citation | Huang, Y.Y.,Deng, J.,Tian, Y.J.,Liang, J.,Xie, X.,Huang, Y.,Zhu, J.,Zhu, Z.,Zhou, Q.,He, X.,Luo, H.B. Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety. J.Med.Chem., 64:13736-13751, 2021 Cited by PubMed: 34520193DOI: 10.1021/acs.jmedchem.1c01085 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.10001966681 Å) |
Structure validation
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