7F2K

Crystal structure of PDE4D catalytic domain complexed with compound 17a

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D	polymer	507	57859.5	2	UniProt (Q08499) Pfam (PF18100) Pfam (PF00233)	Homo sapiens (Human)	DPDE3,PDE43
2	C, F (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, G (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E, H (A, B)	(~{E})-4-[8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-9-oxidanyl-6-oxidanylidene-pyrano[3,2-b]xanthen-5-yl]oxybut-2-enoic acid	non-polymer		492.5	2	Chemie (0X8)
5	I, J (A, B)	water	water		18.0	288	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	115719.0
Non-Polymers*	Number of molecules	6
	Total formula weight	1164.5
All*	Total formula weight	116883.5

*Water molecules are not included.