7CL1
Human SIRT6 in complex with allosteric activator MDL-801 (3.2A)
Summary for 7CL1
Entry DOI | 10.2210/pdb7cl1/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-6, THR-ALA-ARG-LYS-SER-THR-GLY-GLY, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (10 entities in total) |
Functional Keywords | deacylase, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 42248.01 |
Authors | |
Primary citation | Huang, Z.,Zhao, J.,Deng, W.,Chen, Y.,Shang, J.,Song, K.,Zhang, L.,Wang, C.,Lu, S.,Yang, X.,He, B.,Min, J.,Hu, H.,Tan, M.,Xu, J.,Zhang, Q.,Zhong, J.,Sun, X.,Mao, Z.,Lin, H.,Xiao, M.,Chin, Y.E.,Jiang, H.,Shen, H.,Xu, Y.,Chen, G.,Zhang, J. Reply to: Binding site for MDL-801 on SIRT6. Nat.Chem.Biol., 17:522-523, 2021 Cited by PubMed: 33649600DOI: 10.1038/s41589-021-00750-5 PDB entries with the same primary citation |
Experimental method |
Structure validation
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