7CL1
Human SIRT6 in complex with allosteric activator MDL-801 (3.2A)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacetylase sirtuin-6 | polymer | 355 | 39180.9 | 1 | UniProt (Q8N6T7) Pfam (PF02146) | Homo sapiens (Human) | Regulatory protein SIR2 homolog 6,SIR2-like protein 6 |
| 2 | B (C) | THR-ALA-ARG-LYS-SER-THR-GLY-GLY | polymer | 9 | 907.0 | 1 | Homo sapiens (Human) | ||
| 3 | C (A) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 1 | Chemie (AR6) PubChem (25113622) PubChem (25113623) PubChem (44144391) PubChem (44415180) PubChem (33576) PubChem (447165) PubChem (448826) PubChem (51051599) PubChem (9548001) PubChem (9547960) PubChem (174159053) PubChem (89379870) PubChem (91746164) PubChem (192) PubChem (122606931) PubChem (122609061) PubChem (445794) PubChem (447048) PubChem (10437766) PubChem (140853820) PubChem (146879505) PubChem (162774256) PubChem (162782217) PubChem (163972867) PubChem (173750345) PubChem (173750346) PubChem (175675949) | |||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | 5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid | non-polymer | 612.3 | 1 | Chemie (8L9) PubChem (134717373) | |||
| 6 | F, G, H, I (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) PubChem (753) | |||
| 7 | J, M (A, C) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 8 | K (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) | |||
| 9 | L (C) | hexadecanethial | non-polymer | 256.5 | 1 | Chemie (G4X) PubChem (53922026) | |||
| 10 | N, O (A, C) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40087.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2160.1 | |
| All* | Total formula weight | 42248.0 |
