7CD9
Crystal Structure of SETDB1 tudor domain in complexed with Compound 6
Summary for 7CD9
Entry DOI | 10.2210/pdb7cd9/pdb |
Descriptor | Histone-lysine N-methyltransferase SETDB1, 3-methyl-2-[[(3R,5R)-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-5H-pyrrolo[3,2-d]pyrimidin-4-one, CITRIC ACID, ... (4 entities in total) |
Functional Keywords | setdb1, tudor domain, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 56498.43 |
Authors | |
Primary citation | Guo, Y.,Mao, X.,Xiong, L.,Xia, A.,You, J.,Lin, G.,Wu, C.,Huang, L.,Wang, Y.,Yang, S. Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl., 60:8760-8765, 2021 Cited by PubMed: 33511756DOI: 10.1002/anie.202017200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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