7CBJ
Crystal structure of PDE4D catalytic domain in complex with compound 36
Summary for 7CBJ
Entry DOI | 10.2210/pdb7cbj/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | pde4d, inhibitor, complex structure, metal binding protein, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 81886.67 |
Authors | Zhang, X.L.,Xu, Y.C. (deposition date: 2020-06-12, release date: 2021-06-16, Last modification date: 2023-11-29) |
Primary citation | Zhang, R.,Li, H.,Zhang, X.,Li, J.,Su, H.,Lu, Q.,Dong, G.,Dou, H.,Fan, C.,Gu, Z.,Mu, Q.,Tang, W.,Xu, Y.,Liu, H. Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment. Eur.J.Med.Chem., 211:113004-113004, 2021 Cited by PubMed: 33218684DOI: 10.1016/j.ejmech.2020.113004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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