7C7C
Crystal structure of human TRAP1 with SJT104
Summary for 7C7C
Entry DOI | 10.2210/pdb7c7c/pdb |
Descriptor | Heat shock protein 75 kDa, mitochondrial, 2-azanyl-9-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-6-chloranyl-purin-8-ol (2 entities in total) |
Functional Keywords | trpa1, selectivity, mitochondria, hsp90, anticancer, drug, chaperone |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 57794.67 |
Authors | Kim, D.,Yang, S.,Yoon, N.G.,Park, E.,Kim, S.Y.,Kang, B.H.,Lee, C.,Kang, S. (deposition date: 2020-05-24, release date: 2021-05-26, Last modification date: 2023-11-29) |
Primary citation | Yang, S.,Yoon, N.G.,Kim, D.,Park, E.,Kim, S.Y.,Lee, J.H.,Lee, C.,Kang, B.H.,Kang, S. Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. Acs Med.Chem.Lett., 12:1173-1180, 2021 Cited by PubMed: 34267888DOI: 10.1021/acsmedchemlett.1c00213 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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