7BEA
Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor
Summary for 7BEA
Entry DOI | 10.2210/pdb7bea/pdb |
Descriptor | Programmed cell death 1 ligand 1, 2-(aminomethyl)-6-[(2-methyl-3-phenyl-phenyl)methoxy]-~{N}-(2-phenylethyl)imidazo[1,2-a]pyridin-3-amine (3 entities in total) |
Functional Keywords | pd-l1, immune checkpoint, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 29820.10 |
Authors | Magiera-Mularz, K.,Butera, R.,Wazynska, M.,Holak, T.,Domling, A. (deposition date: 2020-12-22, release date: 2021-06-09, Last modification date: 2024-01-31) |
Primary citation | Butera, R.,Wazynska, M.,Magiera-Mularz, K.,Plewka, J.,Musielak, B.,Surmiak, E.,Sala, D.,Kitel, R.,de Bruyn, M.,Nijman, H.W.,Elsinga, P.H.,Holak, T.A.,Domling, A. Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists. Acs Med.Chem.Lett., 12:768-773, 2021 Cited by PubMed: 34055224DOI: 10.1021/acsmedchemlett.1c00033 PDB entries with the same primary citation |
Experimental method |
Structure validation
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