7B8I
Tetragonal structure of human protein kinase CK2 catalytic subunit in complex with a heparin oligo saccharide
Summary for 7B8I
Entry DOI | 10.2210/pdb7b8i/pdb |
Related | 7B8H |
Descriptor | Casein kinase II subunit alpha, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, GLYCEROL, ... (5 entities in total) |
Functional Keywords | protein kinase ck2, casein kinase 2, catalytic subunit ck2alpha, heparin, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 82841.66 |
Authors | Niefind, K.,Schnitzler, A. (deposition date: 2020-12-12, release date: 2021-02-03, Last modification date: 2024-01-31) |
Primary citation | Schnitzler, A.,Niefind, K. Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin. Eur.J.Med.Chem., 214:113223-113223, 2021 Cited by PubMed: 33571828DOI: 10.1016/j.ejmech.2021.113223 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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