7AWE
HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [(1R)-2-(1-benzofuran-3-yl)-1-{[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid
Summary for 7AWE
Entry DOI | 10.2210/pdb7awe/pdb |
Descriptor | Proteasome subunit alpha type-6, Proteasome subunit beta type-3, Proteasome subunit beta type-2, ... (18 entities in total) |
Functional Keywords | multicatalytic proteinase, 20s proteasome, protease, hydrolase, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 28 |
Total formula weight | 695590.05 |
Authors | |
Primary citation | Sanderson, M.P.,Friese-Hamim, M.,Walter-Bausch, G.,Busch, M.,Gaus, S.,Musil, D.,Rohdich, F.,Zanelli, U.,Downey-Kopyscinski, S.L.,Mitsiades, C.S.,Schadt, O.,Klein, M.,Esdar, C. M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i) Delivering Efficacy in Multiple Myeloma Models. Mol.Cancer Ther., 20:1378-1387, 2021 Cited by PubMed: 34045234DOI: 10.1158/1535-7163.MCT-21-0005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.288 Å) |
Structure validation
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