7AVQ
Crystal structure of haspin in complex with disubstituted imidazo[1,2- b]pyridazine inhibitor (compound 12)
Summary for 7AVQ
Entry DOI | 10.2210/pdb7avq/pdb |
Descriptor | Serine/threonine-protein kinase haspin, (2~{R})-2-[[3-(2~{H}-indazol-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, SODIUM ION, ... (6 entities in total) |
Functional Keywords | kinase, haspin, gsg2, inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41359.20 |
Authors | Chaikuad, A.,Bonnet, P.,Routier, S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-11-05, release date: 2020-11-18, Last modification date: 2024-01-31) |
Primary citation | Elie, J.,Feizbakhsh, O.,Desban, N.,Josselin, B.,Baratte, B.,Bescond, A.,Duez, J.,Fant, X.,Bach, S.,Marie, D.,Place, M.,Ben Salah, S.,Chartier, A.,Berteina-Raboin, S.,Chaikuad, A.,Knapp, S.,Carles, F.,Bonnet, P.,Buron, F.,Routier, S.,Ruchaud, S. Design of new disubstituted imidazo[1,2- b ]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation. J Enzyme Inhib Med Chem, 35:1840-1853, 2020 Cited by PubMed: 33040634DOI: 10.1080/14756366.2020.1825408 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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