7AUV
The structure of ERK2 in complex with dual inhibitor ASTX029
Summary for 7AUV
Entry DOI | 10.2210/pdb7auv/pdb |
Descriptor | Mitogen-activated protein kinase 1, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | mitogen activated kinase atp binding protein phosphorylation serine/threonine protein kinase, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43502.28 |
Authors | O'Reilly, M. (deposition date: 2020-11-03, release date: 2021-10-06, Last modification date: 2021-10-13) |
Primary citation | Munck, J.M.,Berdini, V.,Bevan, L.,Brothwood, J.L.,Castro, J.,Courtin, A.,East, C.,Ferraldeschi, R.,Heightman, T.D.,Hindley, C.J.,Kucia-Tran, J.,Lyons, J.F.,Martins, V.,Muench, S.,Murray, C.W.,Norton, D.,O'Reilly, M.,Reader, M.,Rees, D.C.,Rich, S.J.,Richardson, C.J.,Shah, A.D.,Stanczuk, L.,Thompson, N.T.,Wilsher, N.E.,Woolford, A.J.,Wallis, N.G. ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK. Mol.Cancer Ther., 20:1757-1768, 2021 Cited by PubMed: 34330842DOI: 10.1158/1535-7163.MCT-20-0909 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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