7AQ1
Crystal structure of human mature meprin beta in complex with the specific inhibitor MWT-S-270
Summary for 7AQ1
Entry DOI | 10.2210/pdb7aq1/pdb |
Descriptor | Meprin B subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | astacin protease, metalloproteinase, zn dependent, sheddase, gamma secretase, inhbibitor bound meprin beta holoenzyme, intermolecular disulfide bridge homodimer, glycoprotein, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 127877.33 |
Authors | Linnert, M.,Parthier, C.,Fritz, C. (deposition date: 2020-10-20, release date: 2021-03-03, Last modification date: 2024-01-31) |
Primary citation | Linnert, M.,Fritz, C.,Jager, C.,Schlenzig, D.,Ramsbeck, D.,Kleinschmidt, M.,Wermann, M.,Demuth, H.U.,Parthier, C.,Schilling, S. Structure and Dynamics of Meprin beta in Complex with a Hydroxamate-Based Inhibitor. Int J Mol Sci, 22:-, 2021 Cited by PubMed: 34073350DOI: 10.3390/ijms22115651 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.413 Å) |
Structure validation
Download full validation report