7AQ1
Crystal structure of human mature meprin beta in complex with the specific inhibitor MWT-S-270
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Meprin B subunit beta | polymer | 534 | 60788.4 | 2 | UniProt (Q16820) Pfam (PF01400) Pfam (PF00629) Pfam (PF22486) | Homo sapiens (Human) | Endopeptidase-2,Meprin B,N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta,PABA peptide hydrolase,PPH beta |
| 2 | C, E (H, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D (I) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G83161QT) | |||
| 4 | F (L) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G61846BY) | |||
| 5 | G, R (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | H, I, J, S, T (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 7 | K, U (A, B) | 3-[[(3-Carboxyphenyl)methyl-[2-(hydroxyamino)-2-oxoethyl]amino]methyl]benzoic acid | non-polymer | 358.3 | 2 | Chemie (RUE) | |||
| 8 | L, M, V, W (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 9 | N, X (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 10 | O, P, Q, Y, Z (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 11 | AA, BA (A, B) | water | water | 18.0 | 417 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 121576.8 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3805.4 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2495.1 | |
| All* | Total formula weight | 127877.3 |
