7AP4
Thermus thermophilus Aspartyl-tRNA Synthetase in Complex with Compound AspS7HMDDA
Summary for 7AP4
Entry DOI | 10.2210/pdb7ap4/pdb |
Descriptor | Aspartate--tRNA(Asp) ligase, (3~{S})-3-azanyl-4-[[(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxysulfonylamino]-4-oxidanylidene-butanoic acid (3 entities in total) |
Functional Keywords | protein-inhibitor complex, trna aminoacylation, ligase |
Biological source | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
Total number of polymer chains | 2 |
Total formula weight | 133342.57 |
Authors | De Graef, S.,Pang, L.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2020-10-15, release date: 2020-12-09, Last modification date: 2024-01-31) |
Primary citation | Zhang, B.,Pang, L.,Nautiyal, M.,De Graef, S.,Gadakh, B.,Lescrinier, E.,Rozenski, J.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A. Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors. Molecules, 25:-, 2020 Cited by PubMed: 33081246DOI: 10.3390/molecules25204751 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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