7AKB
Structure of DYRK1A in complex with compound 56
Summary for 7AKB
Entry DOI | 10.2210/pdb7akb/pdb |
Related | 7aj2 7aj4 7aj5 7aj7 7aj8 7aja 7ajm 7ajs 7ajv 7ajw 7ajy 7ak2 7aka |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-[3-[2-(6-bromanylpyridin-2-yl)oxyethyl]-2-methyl-imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, phosphoprotein, kinase selectivity, transferase, sbdd, small molecule inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 84174.85 |
Authors | Dokurno, P.,Surgenor, A.E.,Kotschy, A. (deposition date: 2020-09-30, release date: 2021-05-26, Last modification date: 2024-10-09) |
Primary citation | Weber, C.,Sipos, M.,Paczal, A.,Balint, B.,Kun, V.,Foloppe, N.,Dokurno, P.,Massey, A.J.,Walmsley, D.L.,Hubbard, R.E.,Murray, J.,Benwell, K.,Edmonds, T.,Demarles, D.,Bruno, A.,Burbridge, M.,Cruzalegui, F.,Kotschy, A. Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J.Med.Chem., 64:6745-6764, 2021 Cited by PubMed: 33975430DOI: 10.1021/acs.jmedchem.1c00023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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