7A5X
Two copies of the catalytic domain of NanA sialidase from Streptococcus pneumoniae juxtaposed in the P212121 space group, in complex with DANA derivatized with a PEG linker on the glycerol group.
Summary for 7A5X
Entry DOI | 10.2210/pdb7a5x/pdb |
Descriptor | Sialidase A, (4~{S},5~{R},6~{R})-5-acetamido-6-[(1~{R},2~{S})-3-[[1-(2-ethoxyethyl)-1,2,3-triazol-4-yl]methylsulfanyl]-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic acid, SULFATE ION, ... (6 entities in total) |
Functional Keywords | sialidase, catalytic domain, ca170, structural protein |
Biological source | Streptococcus pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 113622.32 |
Authors | Bridot, C.,Bouckaert, J. (deposition date: 2020-08-24, release date: 2020-11-18, Last modification date: 2024-01-31) |
Primary citation | Assailly, C.,Bridot, C.,Saumonneau, A.,Lottin, P.,Roubinet, B.,Krammer, E.M.,Francois, F.,Vena, F.,Landemarre, L.,Alvarez Dorta, D.,Deniaud, D.,Grandjean, C.,Tellier, C.,Pascual, S.,Montembault, V.,Fontaine, L.,Daligault, F.,Bouckaert, J.,Gouin, S.G. Polyvalent Transition-State Analogues of Sialyl Substrates Strongly Inhibit Bacterial Sialidases*. Chemistry, 27:3142-3150, 2021 Cited by PubMed: 33150981DOI: 10.1002/chem.202004672 PDB entries with the same primary citation |
Experimental method |
Structure validation
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