7A5X

Two copies of the catalytic domain of NanA sialidase from Streptococcus pneumoniae juxtaposed in the P212121 space group, in complex with DANA derivatized with a PEG linker on the glycerol group.

Summary for 7A5X

• Entry DOI: 10.2210/pdb7a5x/pdb
• Descriptor: Sialidase A, (4~{S},5~{R},6~{R})-5-acetamido-6-[(1~{R},2~{S})-3-[[1-(2-ethoxyethyl)-1,2,3-triazol-4-yl]methylsulfanyl]-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic acid, SULFATE ION, ... (6 entities in total)
• Functional Keywords: sialidase, catalytic domain, ca170, structural protein
• Biological source: Streptococcus pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 113622.32

Authors

Bridot, C.,Bouckaert, J. (deposition date: 2020-08-24, release date: 2020-11-18, Last modification date: 2024-01-31)

• Primary citation: Assailly, C.,Bridot, C.,Saumonneau, A.,Lottin, P.,Roubinet, B.,Krammer, E.M.,Francois, F.,Vena, F.,Landemarre, L.,Alvarez Dorta, D.,Deniaud, D.,Grandjean, C.,Tellier, C.,Pascual, S.,Montembault, V.,Fontaine, L.,Daligault, F.,Bouckaert, J.,Gouin, S.G.; Polyvalent Transition-State Analogues of Sialyl Substrates Strongly Inhibit Bacterial Sialidases*.; Chemistry, 27:3142-3150, 2021; PubMed: 33150981; DOI: 10.1002/chem.202004672

Experimental method