7A4Q
The Crystal structure of RO4613269 bound to CK2alpha
Summary for 7A4Q
Entry DOI | 10.2210/pdb7a4q/pdb |
Descriptor | Casein kinase II subunit alpha, 2-methoxyimino-5-(quinolin-6-ylmethyl)-1,3-thiazol-4-one (3 entities in total) |
Functional Keywords | selective kinase inhibitors, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 39231.65 |
Authors | Brear, P.,Hyvonen, M. (deposition date: 2020-08-20, release date: 2022-06-08, Last modification date: 2024-01-31) |
Primary citation | Reinecke, M.,Brear, P.,Vornholz, L.,Berger, B.T.,Seefried, F.,Wilhelm, S.,Samaras, P.,Gyenis, L.,Litchfield, D.W.,Medard, G.,Muller, S.,Ruland, J.,Hyvonen, M.,Wilhelm, M.,Kuster, B. Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors. Nat.Chem.Biol., 2023 Cited by PubMed: 37904048DOI: 10.1038/s41589-023-01459-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
Download full validation report