6ZW1

X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with an inhibitor SW101

Summary for 6ZW1

Entry DOI	10.2210/pdb6zw1/pdb
Descriptor	Histone deacetylase 6, ZINC ION, 1-[[4-(oxidanylcarbamoyl)phenyl]methyl]-3,4-dihydro-2~{H}-quinoline-6-carboxamide, ... (7 entities in total)
Functional Keywords	histone deacetylase, deacetylation, inhibitor, danio rerio, hydrolase
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	1
Total formula weight	40668.44
Authors	Barinka, C.,Motlova, L.,Ustinova, K. (deposition date: 2020-07-27, release date: 2021-08-04, Last modification date: 2024-01-31)
Primary citation	Shen, S.,Picci, C.,Ustinova, K.,Benoy, V.,Kutil, Z.,Zhang, G.,Tavares, M.T.,Pavlicek, J.,Zimprich, C.A.,Robers, M.B.,Van Den Bosch, L.,Barinka, C.,Langley, B.,Kozikowski, A.P. Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model. J.Med.Chem., 64:4810-4840, 2021 Cited by PubMed: 33830764 DOI: 10.1021/acs.jmedchem.0c02210 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.13 Å)

Structure validation